What is IGF-1 LR3?

IGF-1 LR3 stands for Long arginine 3-Insulin-like Growth Factor-1. It's a synthetically produced, modified version of the naturally occurring human growth factor, IGF-1. Key alterations include:  

• Arginine substitution: At the third position in its amino acid sequence, it has an arginine instead of glutamic acid.  

• N-terminal extension: An additional 13 amino acids are present at its N-terminus.  

These changes give IGF-1 LR3 a longer half-life and significantly increased potency compared to natural IGF-1.  

How does it work?

IGF-1 LR3 primarily binds to and activates the IGF-1 receptor, mimicking the actions of natural IGF-1. This leads to a cascade of cellular events promoting growth and development. Notably, IGF-1 LR3 has a very low affinity for IGF binding proteins, which normally limit the activity of IGF-1.  

Potential Effects:

• Muscle Growth: IGF-1 LR3 is well-known for its potent ability to stimulate muscle growth by increasing protein synthesis and reducing protein breakdown.

• Fat Loss: It may also contribute to fat loss by increasing metabolic rate and promoting the breakdown of fat cells.

• Improved Recovery: IGF-1 LR3 may aid in recovery from exercise or injury by promoting tissue repair and regeneration.

• Other Potential Effects: Research suggests it may have a role in cognitive function, bone health, and wound healing.

Important Considerations:

• Regulation: The use of IGF-1 LR3 is strictly regulated in many countries, and it's typically only available for research purposes.

• Side Effects: Potential side effects include hypoglycemia (low blood sugar), joint pain, and increased risk of certain cancers.

• Administration: IGF-1 LR3 is typically administered via subcutaneous injection.

• Research is Ongoing: While there's promising research on the effects of IGF-1 LR3, more studies are needed to fully understand its benefits and risks.

The Catalyst Clinic has clinics in London, New York, and Amsterdam. Get in touch today to learn more about IGF-LR3.